| Identification | Back Directory | [Name]
Benzamide, 2-[(3-fluoro-1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]-N-[[4-[[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino]-3-nitrophenyl]sulfonyl]-4-[6-[(2R)-4-[(4-methoxyphenyl)methyl]-2-[2-(1-methylethyl)phenyl]-1-piperazinyl]-2-azaspiro[3.3]hept-2-yl]- | [CAS]
2728752-20-1 | [Synonyms]
Benzamide, 2-[(3-fluoro-1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]-N-[[4-[[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino]-3-nitrophenyl]sulfonyl]-4-[6-[(2R)-4-[(4-methoxyphenyl)methyl]-2-[2-(1-methylethyl)phenyl]-1-piperazinyl]-2-azaspiro[3.3]hept-2-yl]- | [Molecular Formula]
C55H63FN8O8S | [MOL File]
2728752-20-1.mol | [Molecular Weight]
1015.2 |
| Hazard Information | Back Directory | [Uses]
Bcl-2-IN-5 is a BCL-2 inhibitor with IC50s of 0.12 nM, 0.14 nM and 0.22 nM for Bcl-2 wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC50 values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155)[1]. | [IC 50]
Bcl-2: 0.12 nM (IC50); Bcl-2 D103Y: 0.14 nM (IC50); Bcl-2 G101V: 0.22 nM (IC50) | [References]
[1] Hai Xue, et al. Bcl-2 inhibitor. WO2021208963A1. |
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