| Identification | Back Directory | [Name]
13,14-dihydro-15-keto Prostaglandin D2-d9 | [CAS]
2738376-77-5 | [Synonyms]
13,14-dihydro-15-keto Prostaglandin D2-d9 | [Molecular Formula]
C20H23D9O5 | [MOL File]
2738376-77-5.mol | [Molecular Weight]
361.52 |
| Hazard Information | Back Directory | [Uses]
13,14-Dihydro-15-keto prostaglandin D2-d9 (DK-PGD2-d9) is deuterium labeled 13,14-Dihydro-15-keto prostaglandin D2. 13, 14-Dihydro-15-keto prostaglandin D2 (DK-PGD2) is a PGD2 metabolite formed by the 15-hydroxyl PGDH pathway. 13, 14-Dihydro-15-keto prostaglandin D2 is a selective agonist for the DP2 receptor. 13, 14-Dihydro-15-keto prostaglandin D2 can inhibit ion flux in canine colonic mucosa preparation[1][2]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Larsen P, et al. Calcium-stimulated short-circuit currents in the canine proximal colonic epithelium: effects of DK-PGD2, a metabolite of prostaglandin D2. Can J Physiol Pharmacol. 2002 Nov;80(11):1085-94. DOI:10.1139/y02-139 |
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