| Identification | Back Directory | [Name]
2H-Benzimidazol-2-one, 4,5-dichloro-1,3-diethyl-1,3-dihydro- | [CAS]
273930-52-2 | [Synonyms]
2H-Benzimidazol-2-one, 4,5-dichloro-1,3-diethyl-1,3-dihydro- | [Molecular Formula]
C11H12Cl2N2O | [MDL Number]
MFCD17166973 | [MOL File]
273930-52-2.mol | [Molecular Weight]
259.13 |
| Hazard Information | Back Directory | [Uses]
NS4591 is a modulator of calcium-activated potassium channels with activity that enhances small (SK) and intermediate (IK) conductivity. NS4591 doubled IK-mediated currents in whole-cell patch-clamp experiments at a concentration of 45 +/- 6 nM, and doubled SK3-mediated currents at a concentration of 530 +/- 100 nM. NS4591 inhibits the number of action potentials generated by suprathreshold depolarizing pulses in acutely isolated bladder primary afferent neurons. NS4591 also reduced carbakol-induced detrusor ring contraction in the rat bladder, demonstrating sensitivity to apamin[1]. | [References]
[1] A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo |
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