| Identification | Back Directory | [Name]
5-Pyrimidinecarboxamide, 4-[[2-fluoro-6-(trifluoromethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- | [CAS]
2739844-34-7 | [Synonyms]
5-Pyrimidinecarboxamide, 4-[[2-fluoro-6-(trifluoromethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- | [Molecular Formula]
C23H22F4N6O2 | [MOL File]
2739844-34-7.mol | [Molecular Weight]
490.45 |
| Chemical Properties | Back Directory | [Boiling point ]
610.8±65.0 °C(Predicted) | [density ]
1.416±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.88±0.50(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC50 of 0.25 nM. HPK1-IN-3 has IL-2 cellular potency with an EC50 of 108 nM in human peripheral blood mononuclear cells (PBMCs)[1]. | [IC 50]
HPK1: 0.25 nM (IC50) | [References]
[1] Brandon A Vara, et al. Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds. ACS Med Chem Lett. 2021 Mar 19;12(4):653-661. DOI:10.1021/acsmedchemlett.1c00096 |
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