| Identification | Back Directory | [Name]
4-Piperidinecarboxamide, N-[4-(2-benzothiazolyl)phenyl]-1-[(2-chlorophenyl)sulfonyl]- | [CAS]
2756099-59-7 | [Synonyms]
Dual FAAH/sEH-IN-1
Dual FAAH/sEH-IN-1, 10 mM in DMSO
4-Piperidinecarboxamide, N-[4-(2-benzothiazolyl)phenyl]-1-[(2-chlorophenyl)sulfonyl]- | [Molecular Formula]
C25H22ClN3O3S2 | [MOL File]
2756099-59-7.mol | [Molecular Weight]
512.04 |
| Hazard Information | Back Directory | [Uses]
Dual FAAH/sEH-IN-1 (compound 3) is a high affinity dual sEH (soluble epoxide hydrolase) and FAAH (fatty acid amide hydrolase) inhibitor, with IC50 values of 9.6 and 7 nM, respectively. Dual FAAH/sEH-IN-1 shows antinociception against the inflammatory phase[1]. | [References]
[1] Wilt S, Kodani S, Valencia L, et al. Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors. Bioorg Med Chem. 2021;51:116507. DOI:10.1016/j.bmc.2021.116507 |
|
|