| Identification | Back Directory | [Name]
Setmelanotide Acetate(920014728 free base),Setmelanotide Acetate(920014 72 8 free base) | [CAS]
2759937-80-7 | [Synonyms]
Setmelanotide Acetate(920014-72-8 free base)
Setmelanotide Acetate(920014-72-8 free base), 10 mM in DMSO
Setmelanotide Acetate(920014728 free base),Setmelanotide Acetate(920014 72 8 free base) |
| Hazard Information | Back Directory | [Uses]
Setmelanotide (monoacetate) is a melanocortin 4 receptor (MC4R) agonist that acts on human and rat MC4R with EC50 values of 0.27 nM and 0.28 nM, respectively[1][2]. | [References]
[1] Kumar KG, et al. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides. 2009 Oct;30(10):1892-900. DOI:10.1016/j.peptides.2009.07.012
[2] Kievit P, et al. Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes. 2013 Feb;62(2):490-7. DOI:10.2337/db12-0598 |
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