| Identification | Back Directory | [Name]
4-(N-ETHYL-N-4-HYDROXYBUTYL)AMINO-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)PYRROLO[2,3-D]PYRIMIDINE HYDROCHLORIDE | [CAS]
276890-57-4 | [Synonyms]
NIH-3
LWH-63 HYDROCHLORIDE
LWH-63 hydrochloride >=98% (HPLC), solid
1-Butanol, 4-[ethyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-
4-(N-ETHYL-N-4-HYDROXYBUTYL)AMINO-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)PYRROLO[2,3-D]PYRIMIDINE HYDROCHLORIDE
NIH-3, 4-(N-Ethyl-n-4-hydroxybutyl)amino-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidine hydrochloride | [Molecular Formula]
C24H34N4O | [MDL Number]
MFCD07784506 | [MOL File]
276890-57-4.mol | [Molecular Weight]
394.55 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: ~10 mg/mL | [form ]
solid | [color ]
light brown | [InChI]
1S/C24H34N4O.ClH/c1-8-27(11-9-10-12-29)23-21-18(5)19(6)28(24(21)26-20(7)25-23)22-16(3)13-15(2)14-17(22)4;/h13-14,29H,8-12H2,1-7H3;1H | [InChIKey]
DKVWSJKPRJIFPC-UHFFFAOYSA-N | [SMILES]
Cl[H].CCN(CCCCO)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C |
| Hazard Information | Back Directory | [Uses]
CRHR1 antagonist 1 (compound 10a) is a non-peptide corticotropin-releasing hormone type 1 receptor (CRHR1) antagonist. CRHR1 antagonist 1 can be utilized in mental disorders research[1]. | [Biological Activity]
Non-peptide CRF1 corticotrophin-releasing factor antagonist. Ki = 0.68 nM; blocks ethanol-induced effects as well as CRF effects in micesuggesting a possible therapeutic target for the treatment of stress-induced alcohol drinking. | [References]
[1] Hsin LW, et al. Synthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: the development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor. Bioorg Med Chem Lett. 2000 Apr 17;10(8):707-10. DOI:10.1016/s0960-894x(00)00071-8 |
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