| Identification | Back Directory | [Name]
4-[[5-Chloro-4-(5-chloro-2-thienyl)-2-pyrimidinyl]amino]-N-[3-(4-morpholinyl)propyl]benzamide | [CAS]
2797225-49-9 | [Synonyms]
4-[[5-Chloro-4-(5-chloro-2-thienyl)-2-pyrimidinyl]amino]-N-[3-(4-morpholinyl)propyl]benzamide | [Molecular Formula]
C22H23Cl2N5O2S | [MOL File]
2797225-49-9.mol | [Molecular Weight]
492.42 |
| Hazard Information | Back Directory | [Uses]
PfGSK3/PfPK6-IN-1 (compound 23e) is a potent inhibitor of plasmodial kinases PfGSK3 and PfPK6, with IC50s of 97 nM and 8 nM, respectively. PfGSK3/PfPK6-IN-1 exerts antiplasmodial activity against blood stage Pf3D7 parasites with an EC50 value of 1.4 mM[1]. | [References]
[1] Galal KA, et al. Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro. J Med Chem. 2022 Oct 13;65(19):13172-13197. DOI:10.1021/acs.jmedchem.2c00996 |
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