| Hazard Information | Back Directory | [Description]
A spiroisoquinoline alkaloid from Stephania glabra, the base has [α]26D + 143°
(c 1.88, CHCI3). It contains two methoxyl groups and an imino group and yields
a crystalline N-acetyl derivative, m.p. 234-5°C; [α]24D- 80° (c 1.57, CHCI3).
The N-methyl compound has been shown to be identical with Pronuciferine
(q.v.). | [Uses]
Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects[1]. | [in vivo]
Stepharine (500 μg/kg) inhibited NeuN+ cells loss and Iba-1+ cells increase in the MCAO ischemic cortex[1].
| Animal Model: | Middle cerebral artery occlusion (MCAO) rat model[1]. | | Dosage: | 500 μg/kg (20 μL). | | Administration: | Intranasally injected into rats 1h after MCAO. | | Result: | Attenuated the neuronal loss induced by MCAO (MCAO+ stepharine) group. |
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