| Identification | Back Directory | [Name]
Compound 2 | [CAS]
281209-71-0 | [Synonyms]
113683
Compound 2
GLP-1R agonist
GLP1-agonist-2
GLP-1R agonist DMB
GLP-1R agonist DMB-DMB
GLP-1R agonist >=98% (HPLC)
GLP1R Agonist DMB,GLP 1R Agonist DMB
GLP-1R Agonist DMB（GLP-1R agonist 2 ）
Glucagon-Like Peptide 1 Receptor Agonist
N-(tert-butyl)-6,7-dichloro-3-(methylsulfonyl)quinoxalin-2-amine
6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline (DMB)
Glucagon-Like Peptide 1 Receptor Agonist - CAS 281209-71-0 - Calbiochem
2-Quinoxalinamine, 6,7-dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)- | [Molecular Formula]
C13H15Cl2N3O2S | [MDL Number]
MFCD11521508 | [MOL File]
281209-71-0.mol | [Molecular Weight]
348.25 |
| Chemical Properties | Back Directory | [Boiling point ]
535.2±50.0 °C(Predicted) | [density ]
1.423±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥10mg/mL | [form ]
Yellow solid | [pka]
-0.94±0.59(Predicted) | [color ]
light brown-yellow | [InChI]
1S/C13H15Cl2N3O2S/c1-13(2,3)18-11-12(21(4,19)20)17-10-6-8(15)7(14)5-9(10)16-11/h5-6H,1-4H3,(H,16,18) | [InChIKey]
GNZCSGYHILBXLL-UHFFFAOYSA-N | [SMILES]
[S](=O)(=O)(C)c1nc2c(nc1NC(C)(C)C)cc(c(c2)Cl)Cl |
| Hazard Information | Back Directory | [Uses]
GLP-1R agonist 2 (compound 2) is an effective GLP-1R agonist that exerts its activating effect by forming hydrogen bonds with the Tyr42, Cys71, and Ser84 residues of GLP-1R. GLP-1R agonist 2 has the potential for research in metabolic diseases such as type 2 diabetes and obesity[1]. | [General Description]
Glucagon-like peptide-1 receptor (GLP-1R) agonist is a potential oral drug for modulating glucagon-like peptide (GLP)-1 in diabetic patients. GLP-1R agonists play a key role in lowering glycated hemoglobin levels. It improves glycemic control and maintenance of body weight. | [Biochem/physiol Actions]
GLP-1R is a small molecule GLP-1 receptor agonist. GLP-1 receptor signaling is a predominant mechanism for regulating glucose homeostasis. This compound represents a unique non-peptide tool for studying the role of GLP-1 in both in vivo and in vitro diabetes and obesity models. | [References]
[1] Girdhar K, et al. Novel insights into the dynamics behavior of glucagon-like peptide-1 receptor with its small molecule agonists. J Biomol Struct Dyn. 2019 Sep;37(15):3976-3986. DOI:10.1080/07391102.2018.1532818
[2] Knudsen LB, et al. Small-molecule agonists for the glucagon-like peptide 1 receptor. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):937-42. DOI:10.1073/pnas.0605701104 |
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