| Chemical Properties | Back Directory | [Boiling point ]
706.686±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.286±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
2.056±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
PD-1/PD-L1-IN-34 (Compound (1S,2S)-A25) inhibits PD-1/PD-L1 interaction (IC50=0.029 μM), with a selected binding affinity with PD-L1 (KD=0.1554 μM). PD-1/PD-L1-IN-34 inhibits tumor growth by activating the immune microenvironment[1]. | [References]
[1] Jing T, et al. Discovery and Optimization of Novel Biphenyl Derivatives Bearing Cyclopropyl Linkage as Potent Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Inhibitors. J Med Chem. 2023 May 25;66(10):6811-6835. DOI:10.1021/acs.jmedchem.3c00205 |
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