ChemicalBook--->CAS DataBase List--->292618-32-7

292618-32-7

    292618-32-7 Structure

    292618-32-7 Structure
    IdentificationBack Directory
    [Name]

    ST1481
    [CAS]

    292618-32-7
    [Synonyms]

    ST1481
    Lbq707
    CPT 184
    GIMATECAN
    Unii-7kks9R192f
    ST1481: GIMATECAN
    LBQ707; ST1481; CPT 184
    7-T-Butoxyiminomethylcamptothecin
    7-[(E)-tert-butyloxyiminomethyl]-camptothecin
    (4S)-11-((E)-((1,1-Dimethylethoxy)imino)methyl)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione
    1H-Pyrano(3',4':6,7)indolizino(1,2-B)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-(o-(1,1-dimethylethyl)oxime), (C(E),4S)-
    [Molecular Formula]

    C25H25N3O5
    [MDL Number]

    MFCD06795143
    [MOL File]

    292618-32-7.mol
    [Molecular Weight]

    447.49
    Chemical PropertiesBack Directory
    [Boiling point ]

    780.6±70.0 °C(Predicted)
    [density ]

    1.37±0.1 g/cm3(Predicted)
    [storage temp. ]

    Store at -20°C
    [form ]

    Solid
    [pka]

    11.20±0.20(Predicted)
    [color ]

    Light yellow to yellow
    Safety DataBack Directory
    [Symbol(GHS) ]

    Exclamation Mark (GHS07)Health Hazard (GHS08)Skull and Crossbones (GHS06)
    GHS07,GHS08,GHS06
    [Signal word ]

    Danger
    [Hazard statements ]

    H300-H335-H319-H351-H315
    [Precautionary statements ]

    P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
    Hazard InformationBack Directory
    [Uses]

    Gimatecan (ST1481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity[1].
    [Biological Activity]

    Gimatecan (ST1481) is a potent topoisomerase I inhibitor. It is an orally active camptothecin analog with antineoplastic activity.
    [in vivo]

    Gimatecan (2 mg/kg; treatment per os, every fourth day for four times) is effective for inhibiting tumor growth.

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    table>
    Animal Model: Athymic Swiss nude mice bearing HT1376 model
    Dosage: 2 mg/kg
    Administration: Treatment per os, every fourth day for four times
    Result: Caused a marked tumor growth inhibition during treatment.
    [target]

    Topoisomerase I

    [IC 50]

    Topoisomerase I
    [storage]

    Store at -20°C
    [References]

    [1] Paola Ulivi, et al. Cellular Basis of Antiproliferative and Antitumor Activity of the Novel Camptothecin Derivative, Gimatecan, in Bladder Carcinoma Models. Neoplasia. 2005 Feb;7(2):152-61. DOI:10.1593/neo.04397
    Spectrum DetailBack Directory
    [Spectrum Detail]

    ST1481(292618-32-7)1HNMR
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