| Identification | Back Directory | [Name]
Ozanimod Impurity 8 | [CAS]
2990018-57-8 | [Synonyms]
Ozanimod Impurity 8
Ozanimod Impurity 9
(S)-1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-indene-4-carboximidamide
(S)-N-hydroxy-1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-indene-4-carboximidamide
Glycine, N-[(1S)-4-[5-[3-cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]- | [Molecular Formula]
C23H22N4O4 | [MOL File]
2990018-57-8.mol | [Molecular Weight]
418.45 |
| Chemical Properties | Back Directory | [Boiling point ]
664.8±65.0 °C(predicted) | [density ]
1.36±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
2.33±0.10(predicted) | [color ]
Off-white to light yellow | [InChIKey]
HICWSCLKDYAXPD-IBGZPJMESA-N | [SMILES]
N([C@H]1CCC2C1=CC=CC=2C1=NOC(C2C=CC(=C(C=2)C#N)OC(C)C)=N1)CC(=O)O |
| Hazard Information | Back Directory | [Uses]
RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely[1]. | [IC 50]
S1PR1: 0.19 nM (EC50); S1PR5: 32.8 nM (EC50) | [References]
[1] Tran JQ, et al. Cardiac Safety of Ozanimod, a Novel Sphingosine-1-Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study. Clin Pharmacol Drug Dev. 2018;7(3):263-276. DOI:10.1002/cpdd.383
[2] Gilardi D, et al. PK, PD, and interactions: the new scenario with JAK inhibitors and S1P receptor modulators, two classes of small molecule drugs, in IBD [published online ahead of print, 2020 Jul 1]. Expert Rev Gastroenterol Hepatol. 2020;1-10. DOI:10.1080/17474124.2020.1785868 |
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