| Identification | Back Directory | [Name]
Morpholine, 4-[[(3R)-1-[[3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]methyl]-3-piperidinyl]methyl]- | [CAS]
3031984-80-9 | [Synonyms]
Morpholine, 4-[[(3R)-1-[[3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]methyl]-3-piperidinyl]methyl]- | [Molecular Formula]
C20H25F3N4O2 | [MOL File]
3031984-80-9.mol | [Molecular Weight]
410.43 |
| Chemical Properties | Back Directory | [Boiling point ]
490.3±55.0 °C(predicted) | [density ]
1.258±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
7.28±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
(R)-V-0219 is an enantiomer of V-0219 (HY-143312). V-0219 is an orally active and positive allosteric modulator (PAM) of the?GLP Receptor-1 (GLP-1R). (R)-V-0219 activates calcium fluxes in HEK cells stably expressing hGLP-1R[1]. | [References]
[1] Decara JM, et al. Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity". J Med Chem. 2022 Apr 14;65(7):5449-5461. DOI:10.1021/acs.jmedchem.1c01842 |
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