| Identification | Back Directory | [Name]
??L1Au2 | [CAS]
3038386-42-1 | [Synonyms]
??L1Au2
Gold, [3-[[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-propyn-1-yl](1,3,5-triaza-7-phosphatricyclo[3.3.1.13,7]decane-κP7)- | [Molecular Formula]
C24H24AuClFN6O2P | [MOL File]
3038386-42-1.mol | [Molecular Weight]
710.88 |
| Hazard Information | Back Directory | [Description]
L1Au2 is a dual inhibitor of EGFR and thioredoxin reductase (TrxR; IC50 = 0.99 μM).{72756|} It inhibits the phosphorylation of EGFR, Akt, and ERK in PC-9 lung cancer cells, which express EGFR containing the exon 19 deletion, when used at concentrations of 0.01 or 0.05 μM. L1Au2 inhibits the proliferation of PC-9 and gefitinib-resistant PC-9 cells (IC50s = 0.012 and 1.76 μM, respectively) and induces ferroptosis in gefitinib-resistant PC-9 cells. In vivo, L1Au2 (10 mg/kg) decreases tumor weight and intratumoral glutathione peroxidase 4 (Gpx4) levels in a gefitinib-resistant PC-9 mouse xenograft model.WARNING This product is not for human or veterinary use. |
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