| Identification | Back Directory | [Name]
mepacrine mesilate | [CAS]
316-05-2 | [Synonyms]
Musonal
Einecs 206-256-1
mepacrine mesilate
quinacrine mesylate
Mepacrine methanesulfonate
Quinacrine methanesulfonate
Mepacrine dimethanesulfonate salt
1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-, dimethanesulfonate
Acridine, 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-, dimethanesulfonate | [EINECS(EC#)]
206-256-1 | [Molecular Formula]
C24H34ClN3O4S | [MOL File]
316-05-2.mol | [Molecular Weight]
496.06 |
| Hazard Information | Back Directory | [Uses]
Quinacrine (Mepacrine) methanesulfonate is a potent, orally active antimalarial agent with antitumor effects in vitro and in vivo. Quinacrine dihydrochloride inhibits NF-κB and activates p53 signaling, inducing apoptosis in tumor cells[1][2]. | [References]
[1] Xiaoyang Wu, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73(1-2):52-64. DOI:10.1016/j.curtheres.2012.02.003
[2] Anna Eriksson, et al. Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects. Leuk Res. 2017 Dec;63:41-46. DOI:10.1016/j.leukres.2017.10.012 |
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