ChemicalBook--->CAS DataBase List--->31750-48-8

31750-48-8

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      31750-48-8 Structure

      31750-48-8 Structure
      IdentificationBack Directory
      [Name]

      N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
      [CAS]

      31750-48-8
      [Synonyms]

      ici55,548
      desmethyltamoxifen
      n-desmethyltamoxifen
      Tamoxifen EP Impurity F
      N-DESMETHYL TAMOXIFEN HCL
      N-DEMETHYLTAMOXIFEN, HYDROCHLORIDE
      N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
      2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(4-((z)-ethanamin
      2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(p-((z)-ethylamin
      cis-2-(p-(1,2-diphenyl-1-butenyl)phenoxy)-n-methylethylamine
      (Z)-2-[4-(1,2-DIPHENYL-1-BUTENYL)PHENOXY]-N-METHYL-ETHANAMINE
      (Z)-2-(4-(1,2-diphenylbut-1-en-1-yl)phenoxy)-N-methylethanamine
      Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N-methyl-
      2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methylethanamine HCl
      [Molecular Formula]

      C25H27NO
      [MDL Number]

      MFCD03423594
      [MOL File]

      31750-48-8.mol
      [Molecular Weight]

      357.49
      Chemical PropertiesBack Directory
      [Boiling point ]

      485.8±33.0 °C(Predicted)
      [density ]

      1.047±0.06 g/cm3(Predicted)
      [storage temp. ]

      Store at -20°C
      [solubility ]

      DMSO: 72 mg/mL (201.40 mM);Ethanol: 36 mg/mL (100.70 mM)
      [pka]

      9.38±0.10(Predicted)
      [Water Solubility ]

      Water: Insoluble
      Safety DataBack Directory
      [Symbol(GHS) ]

      Health Hazard (GHS08)Exclamation Mark (GHS07)
      GHS08,GHS07
      [Signal word ]

      Danger
      [Hazard statements ]

      H350-H302-H372-H360
      [Precautionary statements ]

      P264-P270-P301+P312-P330-P501-P260-P264-P270-P314-P501
      Hazard InformationBack Directory
      [Definition]

      ChEBI: N-Desmethyltamoxifen is a stilbenoid.
      [Biological Activity]

      N-Desmethyltamoxifen is the main metabolite of Tamoxifen in the human body. N-Desmethyltamoxifen, a weaker antiestrogen, is a protein kinase C (PKC) inhibitor ten times stronger than Tamoxifen. It is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis and sphingosine phosphorylation.
      [in vitro]

      N-desmethyltamoxifen (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells).
      It inhibits growth of MCF 7 human mammary carcinoma cells.
      N-desmethyltamoxifen, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen.

      Cell Viability Assay

      td>
      Cell Line: MCF 7 human mammary carcinoma cells
      Concentration: 1.5, 2.5, 5, 7.5, 10 μM
      Incubation Time: 114 hours
      Result: Inhibits growth of MCF 7 human mammary carcinoma cells
      [target]

      < /table>

      PKC

      Estrogen Receptor

      [storage]

      Store at -20°C
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      Tags:31750-48-8 Related Product Information
      10540-29-1

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