| Identification | Back Directory | [Name]
IMR-1A | [CAS]
331862-41-0 | [Synonyms]
IMR-1A
IMR-1A, >98%
IMR1A;IMR 1A;IMR-1A
Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]- | [Molecular Formula]
C13H11NO5S2 | [MDL Number]
MFCD04083080 | [MOL File]
331862-41-0.mol | [Molecular Weight]
325.36 |
| Chemical Properties | Back Directory | [density ]
1.55±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO:4.0(Max Conc. mg/mL);12.29(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);3.07(Max Conc. mM) | [form ]
Solid | [pka]
3.10±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
IMR-1A is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. It has antitumor activity. | [in vivo]
IMR-1A (2 mg/kg (iv) and 100 mg/kg (ip)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/ 2) of 2.22 h following a single iv administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration. | Animal Model: | Male C57 BL/6 mice | | Dosage: | 2 mg/kg (iv) and 100 mg/kg (ip) | < td class="col1 fwb"> Administration: | Iv and ip | | Result: | Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single iv administration and plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration. | | [target]
| Target | Value | Notch
(Cell-free assay) | 0.5 μM | Notch
(Cell-free assay) | 2.9 μM(Kd) | < /table>
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|
|
Tags:331862-41-0
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