| Identification | Back Directory | [Name]
2-methyl-5-{4-[(4-sulfamoylphenyl)amino]phthalazin-1-yl}benzenesulfonamide | [CAS]
333413-02-8 | [Synonyms]
2-methyl-5-{4-[(4-sulfamoylphenyl)amino]phthalazin-1-yl}benzenesulfonamide
Benzenesulfonamide, 5-[4-[[4-(aminosulfonyl)phenyl]amino]-1-phthalazinyl]-2-methyl- | [Molecular Formula]
C21H19N5O4S2 | [MOL File]
333413-02-8.mol | [Molecular Weight]
469.54 |
| Hazard Information | Back Directory | [Biological Activity]
ENPP3 inhibitor is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3; Ki = 53.7 nM).1 It is selective for ENPP3 over ENPP1, ENPP2, tissue-nonspecific alkaline phosphatase (TNAP), ecto-5′-nucleotidase (CD73), nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1), NTPDase 2, and NTPDase 3. ENPP3 inhibitor also inhibits carbonic anhydrase II (CAII) and CAIX (Kis = 74.7 and 20.3 nM, respectively). | [References]
1.Lee, S.-Y., Namasivayam, V., Boshta, N.M., et al.Discovery of potent nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) inhibitors with ancillary carbonic anhydrase inhibition for cancer (immuno)therapyRSC Med. Chem.12(7)1187-1206(2021)
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