| Identification | Back Directory | [Name]
N-[3-(2,2-dimethyloxan-4-yl)-3-(2-methoxyphenyl)propyl]-N-[(4-methoxyphenyl)methyl]furan-2-carboxamide | [CAS]
337486-54-1 | [Synonyms]
N-[3-(2,2-dimethyloxan-4-yl)-3-(2-methoxyphenyl)propyl]-N-[(4-methoxyphenyl)methyl]furan-2-carboxamide
2-Furancarboxamide, N-[(4-methoxyphenyl)methyl]-N-[3-(2-methoxyphenyl)-3-(tetrahydro-2,2-dimethyl-2H-pyran-4-yl)propyl]- | [Molecular Formula]
C30H37NO5 | [MOL File]
337486-54-1.mol | [Molecular Weight]
491.62 |
| Hazard Information | Back Directory | [Uses]
ICMT-IN-48 (compound 1) is an ICMT inhibitor that is competitive (Km=13 μM) for the prenylated methyl acceptor, the first substrate of ICMT. ICMT-IN-48 inhibits ICMT activity with IC50s affected by the concentration of the second substrate S-adenosylmethinine (SAM), and the IC50s are 3.5 μM (1×Km SAM) and 2.3 μM (10×Km SAM), respectively[1]. | [References]
[1] Judd WR, et al. Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT). J Med Chem. 2011 Jul 28;54(14):5031-47. DOI:10.1021/jm200249a |
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