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340306-87-8

340306-87-8 Structure

340306-87-8 Structure
IdentificationBack Directory
[Name]

4,6(1H,5H)-Pyrimidinedione, 5-[[5-(2,3-dichlorophenyl)-2-furanyl]methylene]dihydro-1-(2-propen-1-yl)-2-thioxo-
[CAS]

340306-87-8
[Synonyms]

SIRT5 inhibitor 2
4,6(1H,5H)-Pyrimidinedione, 5-[[5-(2,3-dichlorophenyl)-2-furanyl]methylene]dihydro-1-(2-propen-1-yl)-2-thioxo-
[Molecular Formula]

C18H12Cl2N2O3S
[MOL File]

340306-87-8.mol
[Molecular Weight]

407.27
Chemical PropertiesBack Directory
[density ]

1.52±0.1 g/cm3(Predicted)
[pka]

5.70±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

SIRT5 inhibitor 2 (compound 49) is a potent SIRT5 inhibitor with an IC50 value of 2.3 μM. SIRT5 inhibitor 2 has inhibitory activity against the SIRT5-dependent desuccinylation. SIRT5 inhibitor 2 can be used for researching cancer and neurodegenerative diseases[1].
[IC 50]

SIRT5: 2.3 μM (IC50)
[References]

[1] Wang Y, et al. Overview of SIRT5 as a potential therapeutic target: Structure, function and inhibitors. Eur J Med Chem. 2022;236:114363. DOI:10.1016/j.ejmech.2022.114363
Spectrum DetailBack Directory
[Spectrum Detail]

4,6(1H,5H)-Pyrimidinedione, 5-[[5-(2,3-dichlorophenyl)-2-furanyl]methylene]dihydro-1-(2-propen-1-yl)-2-thioxo-(340306-87-8)1HNMR
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