| Identification | Back Directory | [Name]
hypusine | [CAS]
34994-11-1 | [Synonyms]
hypusine
L-Lysine, N6-[(2R)-4-amino-2-hydroxybutyl]-
(2S)-2-aMino-6-[[(2S)-4-aMino-2-hydroxybutyl]aMino]hexanoic
(2S)-2-aMino-6-[[(2S)-4-aMino-2-hydroxybutyl]aMino]hexanoic acid | [Molecular Formula]
C10H23N3O3 | [MDL Number]
MFCD27949784 | [MOL File]
34994-11-1.mol | [Molecular Weight]
233.31 |
| Chemical Properties | Back Directory | [Boiling point ]
465.2±45.0 °C(Predicted) | [density ]
1.151±0.06 g/cm3(Predicted) | [pka]
2.50±0.24(Predicted) | [Optical Rotation]
(2S, 9R)-：+9.916 (6 mol dm-3 HCl) (2S,9S)-：+1623 (6 mol dm-3 HCl) |
| Hazard Information | Back Directory | [Uses]
Hypusine is a natural amino acid. The post-translational synthesis of hypusine is mainly catalyzed by deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH)[1][2]. | [Definition]
ChEBI: An L-lysine derivative that is L-lysine bearing a (2R)-4-amino-2-hydroxybutyl substituent at position N6. | [IC 50]
Human Endogenous Metabolite | [References]
[1] Shiba T,et al. Hypusine, a new amino acid occurring in bovine brain. Isolation and structural determination. Biochim Biophys Acta. 1971 Sep 21;244(3):523-31. DOI:10.1016/0304-4165(71)90069-9
[2] ark MH, et al. Hypusine, a polyamine-derived amino acid critical for eukaryotic translation. J Biol Chem. 2018 Nov 30;293(48):18710-18718. DOI:10.1074/jbc.TM118.003341 |
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