| Identification | Back Directory | [Name]
JP 92, NSC 43036, S-(+)-α-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride | [CAS]
37936-89-3 | [Synonyms]
JP 92
NSC 43036
(+)-Norfenfluramine
)-Norfenfluramine hydrochloride
(+)-NORFENFLURAMINE HYDROCHLORIDE
(S)-1-(3-(trifluoromethyl)phenyl)propan-2-amine HCl
(S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE HYDROCHLORIDE
(S)-1-(3-(trifluoromethyl)phenyl)propan-2-amine hydrochloride
S-(+)-alpha-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
JP 92, NSC 43036, S-(+)-α-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
JP 92, NSC 43036, S-(+)-alpha-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride | [Molecular Formula]
C10H12F3N.ClH | [MDL Number]
MFCD11045299 | [MOL File]
37936-89-3.mol | [Molecular Weight]
239.667 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: >10mg/mL | [form ]
powder | [color ]
white | [Water Solubility ]
H2O: >10mg/mL | [InChI]
1S/C10H12F3N.ClH/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13;/h2-4,6-7H,5,14H2,1H3;1H/t7-;/m0./s1 | [InChIKey]
PIDLOFBRTWNFAR-FJXQXJEOSA-N | [SMILES]
Cl.C[C@H](N)Cc1cccc(c1)C(F)(F)F |
| Hazard Information | Back Directory | [Uses]
(S)-Norfenfluramine Hydrochloride is a metabolite of (S)-(+)-Fenfluramine Hydrochloride (F247596); an anorexic. | [Biochem/physiol Actions]
(+)-Norfenfluramine is the major hepatic metabolite of (+)-fenfluramine and is primarily responsible for the anorexic effect, as well as side effects; (+)-norfenfluramine causes vasoconstriction and a blood pressure increase in rats with normal blood; acts primarily on the cytoplasmic pool of serotonin; more potent than fenfluramine at inducing dopamine release. | [in vivo]
(+)-Norfenfluramine (1-300 μg/kg, i.v.) hydrochloride induces pressor response in conscious SHAM and DOCA-salt rats[1].
(+)-Norfenfluramine (2.5 and 5 mg/kg, i.p.) hydrochloride decreases of 5-HT and 5-HIAA levels in telencephalon and brainstem of rats[3].
| Animal Model: | Conscious SHAM and DOCA-salt rats[1].
| | Dosage: | 1-300 μg/kg | | Administration: | Intravenous injection (i.v.), given in a cumulative fashion at 6-min intervals. | | Result: | Induced pressor response in conscious SHAM and DOCA-salt rats. (change in mean arterial blood pressure at 300 μg/kg, mm Hg, SHAM vehicle=36, SHAM ketanserin=7, DOCA=51, DOCA ketanserin=19). |
| [IC 50]
5-HT2B Receptor: 11.2 nM (Ki); 5-HT2C Receptor: 324 nM (Ki); 5-HT2A Receptor: 1516 nM (Ki) |
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