| Identification | Back Directory | [Name]
187-1, N-WASP INHIBITOR | [CAS]
380488-27-7 | [Synonyms]
CYCLO(LKDFDPDFLFDPLQ)2
187-1, N-WASP INHIBITOR
N-WASP-INHIBITOR, 187-1
M.W. 1784.13 C96H122N18O16
Cyclo(L-glutaminyl-L-lysyl-D-phenylalanyl-D-prolyl-D-phenylalanyl-L-phenylalanyl-D-prolyl-L-glutaminyl-L-lysyl-D-phenylalanyl-D-prolyl-D-phenylalanyl-L-phenylalanyl-D-prolyl) | [Molecular Formula]
C96H122N18O16 | [MDL Number]
MFCD04974218 | [MOL File]
380488-27-7.mol | [Molecular Weight]
1784.11 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO: 1mg/mL
acetic acid: 5% | [form ]
Powder | [color ]
White to off-white | [Water Solubility ]
Soluble to 2 mg/ml in water | [Sequence]
Cyclo[Gln-Lys-{d-Phe}-{d-Pro}-{d-Phe}-Phe-{d-Pro}-Gln-Lys-{d-Phe}-{d-Pro}-{d-Phe}-Phe-{d-Pro}] |
| Hazard Information | Back Directory | [Uses]
187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein[1][2]. | [Biological Activity]
Primary Target
Neural Wiskott Aldrich syndrome protein (N-WASP)''Target IC50: ~ 2 μM blocking phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract | [References]
[1] Peterson, et al. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10624-9. DOI:10.1073/pnas.201393198
[2] S Suetsugu, et al. Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J DOI:10.1074/jbc.M102866200 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Fuan Bio
|
| Tel: |
15002819872 |
| Website: |
fuanbio.com |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|