| Identification | Back Directory | [Name]
11H-1,3-Dioxolo[4,5-h]imidazo[1,2-c][2,3]benzodiazepine, 8,9-dimethyl-5-phenyl- | [CAS]
397298-63-4 | [Synonyms]
ZK187638
11H-1,3-Dioxolo[4,5-h]imidazo[1,2-c][2,3]benzodiazepine, 8,9-dimethyl-5-phenyl- | [Molecular Formula]
C20H17N3O2 | [MOL File]
397298-63-4.mol | [Molecular Weight]
331.37 |
| Hazard Information | Back Directory | [Uses]
ZK 187638 is an AMPA receptor antagonist. ZK 187638 antagonizes the kainate-induced currents in cultured hippocampal neurons with an IC50 of 3.4 μM in a noncompetitive fashion[1]. | [References]
[1] Bernd Elger, et al. Novel alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor antagonists of 2,3-benzodiazepine type: chemical synthesis, in vitro characterization, and in vivo prevention of acute neurodegeneration. J Med Chem. 2005 Jul 14;48(14):4618-27. DOI:10.1021/jm0580003 |
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