15231-91-1

442150-49-4

Under argon protection, 4.46 g (0.02 mol) of 6-bromo-2-naphthol with 250 mL of acetonitrile was added to a 250 mL three-necked flask and stirred until completely dissolved. Subsequently, 8.50 g (0.024 mol) of Selectfluor was added to the solution. the reaction mixture was heated to 60 °C with continuous stirring for 12 h. The reaction was completed by pouring the reaction mixture into the flask. Upon completion of the reaction, the mixture was poured into 100 mL of water and extracted by adding 150 mL of ethyl acetate. After stirring, the mixture was left to stratify and the organic phase was separated. The organic phase was washed three times with water, dried with anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography, and the eluent was a mixed system of petroleum ether/ethyl acetate. The target fraction was collected and the solvent was removed by rotary evaporation to give a yellow solid. After standing at room temperature, a large amount of yellow solid was precipitated, filtered and dried to give 2.64 g of 6-bromo-1-fluoro-2-naphthol in 54.6% yield.