| Identification | Back Directory | [Name]
BenzenesulfonaMide, 2,5-diMethoxy-N-3-quinolinyl- | [CAS]
496014-13-2 | [Synonyms]
2,5-dimethoxy-N-quinolin-3-ylbenzenesulfonamide
2,5-Dimethoxy-N-(3-quinolinyl)benzenesulfonamide
BenzenesulfonaMide, 2,5-diMethoxy-N-3-quinolinyl- | [Molecular Formula]
C17H16N2O4S | [MOL File]
496014-13-2.mol | [Molecular Weight]
344.38 |
| Chemical Properties | Back Directory | [Boiling point ]
564.1±60.0 °C(Predicted) | [density ]
1.356±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 50mg/mL | [form ]
solid | [pka]
7.48±0.30(Predicted) | [color ]
white | [InChI]
1S/C17H16N2O4S/c1-22-14-7-8-16(23-2)17(10-14)24(20,21)19-13-9-12-5-3-4-6-15(12)18-11-13/h3-11,19H,1-2H3 | [InChIKey]
JZSPHTPWUXNQGB-UHFFFAOYSA-N | [SMILES]
[S](=O)(=O)(Nc2cnc3c(c2)cccc3)c1c(ccc(c1)OC)OC |
| Hazard Information | Back Directory | [Uses]
TNAP-IN-1 (Compound 1) is a selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor, with an IC50 of 0.19 μM. TNAP-IN-1 can be used for the research of soft tissue calcification[1]. | [Definition]
ChEBI: 2,5-dimethoxy-N-(3-quinolinyl)benzenesulfonamide is a member of quinolines. | [References]
[1] Dahl R, et al. Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). J Med Chem. 2009 Nov 12;52(21):6919-25. DOI:10.1021/jm900383s |
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