| Identification | Back Directory | [Name]
2-Propen-1-one, 1-(2,3-dihydroxy-4,6-dimethoxyphenyl)-3-phenyl- | [CAS]
54299-64-8 | [Synonyms]
2-Propen-1-one, 1-(2,3-dihydroxy-4,6-dimethoxyphenyl)-3-phenyl- | [Molecular Formula]
C17H16O5 | [MOL File]
54299-64-8.mol | [Molecular Weight]
300.31 |
| Chemical Properties | Back Directory | [Melting point ]
137-139 °C(Solvent: Methanol) | [Boiling point ]
556.0±50.0 °C(predicted) | [density ]
1.279±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
6.65±0.45(predicted) |
| Hazard Information | Back Directory | [Uses]
2',3'-Dihydroxy-4',6'-dimethoxychalcone (compound 1) can inhibit Amyloid β-protein (Aβ42) fibrillization and aggregation. 2',3'-Dihydroxy-4',6'-dimethoxychalcone has oral activity and can be detected in the brain[1]. | [References]
[1] Jacob P Beard, et al. Synthesis and Conformational Analysis of FR901464-Based RNA Splicing Modulators and Their Synergism in Drug-Resistant Cancers. J Med Chem. 2023. DOI:10.1021/acs.jmedchem.3c00733 |
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