| Identification | Back Directory | [Name]
6-(4-ethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | [CAS]
578723-96-3 | [Synonyms]
CID663143
CID-663143
CID 663143
CID-663143, 10 mM in DMSO
6-(4-ethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine, 6-(4-ethoxyphenyl)-3-(2-methoxyphenyl)- | [Molecular Formula]
C19H18N4O2S | [MOL File]
578723-96-3.mol | [Molecular Weight]
366.44 |
| Hazard Information | Back Directory | [Uses]
CID-663143 targets microtubule-associated proteins, not tubulin itself, to inhibit the polymerization process within cells. CID-663143 inhibits cancer cell growth (IC50: <100 nM for HT-1080, BJeLR, MCF10A cells)[1]. | [References]
[1] Yang WS, et al. Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency. ACS Med Chem Lett. 2012 Jan 12;3(1):35-38. DOI:10.1021/ml200195s |
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