| Identification | Back Directory | [Name]
KJ Pyr 9 | [CAS]
581073-80-5 | [Synonyms]
KJ Pyrq
KJ Pyr 9
4-[2-(2-Furanyl)-6-(4-nitrophenyl)-4-pyridinyl]benzamide
Benzamide, 4-[2-(2-furanyl)-6-(4-nitrophenyl)-4-pyridinyl]- | [Molecular Formula]
C22H15N3O4 | [MOL File]
581073-80-5.mol | [Molecular Weight]
385.37 |
| Chemical Properties | Back Directory | [Boiling point ]
584.4±50.0 °C(Predicted) | [density ]
1.320±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≤20mg/ml in DMSO;25mg/ml in dimethyl formamide | [form ]
crystalline solid | [pka]
15.34±0.50(Predicted) | [color ]
Light yellow to yellow | [InChI]
1S/C22H15N3O4/c23-22(26)16-5-3-14(4-6-16)17-12-19(15-7-9-18(10-8-15)25(27)28)24-20(13-17)21-2-1-11-29-21/h1-13H,(H2,23,26) | [InChIKey]
GTTDVYCKFQYVNN-UHFFFAOYSA-N | [SMILES]
[N+](=O)([O-])c1ccc(cc1)c2nc(cc(c2)c4ccc(cc4)C(=O)N)c3[o]ccc3 |
| Hazard Information | Back Directory | [Uses]
4-[2-(2-Furanyl)-6-(4-nitrophenyl)-4-pyridinyl]benzamide is a inhibits MYC-induced oncogenic transformation in cell culture and blocks the growth of a xenotransplant of MYC-amplified human cancer cells. | [Biological Activity]
mkj pyr 9 is a novel small molecule inhibitor of myc, with the kd value of 6.5 ± 1.0 nm. besides, kj pyr 9 also suppresses the formation of myc-max and oncogenic transformation induced by myc in cell culture [1]. | [in vitro]
in chicken embryo fibroblasts, kj pyr 9 was found to have the ability to interfere with the oncogenic activity of myc, with the best aqueous solubility. besides, in human b-cell line p493-6, 20 μm kj pyr 9 could significantly inhibit cell proliferation, and kj pyr 9 could also inhibit the proliferation of nci-h460, mda-mb-231, and sum-159pt cell lines, with the ic50 values between 5-10 μm. furthermore, treatment of p493-6 cells with kj pyr 9 could significantly suppress the transcription ability of myc [1]. | [in vivo]
kj pyr 9 was found to have no acute toxicity in mouse and rat at a dose of 10 mg/kg, with an impressive ability to cross the blood-brain barrier. besides, in a mda-mb-231 cells xenograft tumor nude mice model, intraperitoneal injection with 10 mg/kg kj pyr 9 for 31 days could significantly inhibit tumor growth, while having no effect on the body weight [1]. | [target]
myc | [storage]
Store at +4°C | [References]
[1] hart j r, garner a l, yu j, et al. inhibitor of myc identified in a kr?hnke pyridine library[j]. proceedings of the national academy of sciences, 2014, 111(34): 12556-12561. |
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BOC Sciences
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Musechem
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www.musechem.com |
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cjbscvictory
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