| Identification | Back Directory | [Name]
L-Tryptophan, L-isoleucyl-L-alanyl-L-leucyl-L-tyrosyl-L-leucyl-L-glutaminyl-L-glutaminyl-L-asparaginyl- | [CAS]
610268-80-9 | [Synonyms]
L-Tryptophan, L-isoleucyl-L-alanyl-L-leucyl-L-tyrosyl-L-leucyl-L-glutaminyl-L-glutaminyl-L-asparaginyl- | [Molecular Formula]
C55H81N13O14 | [MOL File]
610268-80-9.mol | [Molecular Weight]
1148.31 |
| Chemical Properties | Back Directory | [Boiling point ]
1608.8±65.0 °C(predicted) | [density ]
1.289±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
3.32±0.10(predicted) | [color ]
White to off-white | [Sequence]
Ile-Ala-Leu-Tyr-Leu-Gln-Gln-Asn-Trp |
| Hazard Information | Back Directory | [Uses]
IALYLQQNW is a specific nonapeptide sequence derived from the tumor-associated antigen latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus (EBV). As a latent T-cell epitope, IALYLQQNW is able to activate EBV-specific cytotoxic T lymphocytes (CTLs), which are able to recognize and kill EBV-infected cells expressing LMP1. IALYLQQNW plays an important role in the immune response against EBV-associated tumors and can be used in the study of Hodgkin's disease and nasopharyngeal carcinoma[1]. | [References]
[1] Duraiswamy, et al. "Ex vivo analysis of T-cell responses to Epstein-Barr virus-encoded oncogene latent membrane protein 1 reveals highly conserved epitope sequences in virus isolates from diverse geographic regions." Journal of virology 77.13 (2003): 7401-7410. DOI:10.1128/jvi.77.13.7401-7410.2003 |
|
|