| Identification | Back Directory | [Name]
Benzo[g]pteridine-2,4(3H,10H)-dione, 10-(2-methoxyethyl)-3-phenyl- | [CAS]
61369-43-5 | [Synonyms]
NSC 288387
Benzo[g]pteridine-2,4(3H,10H)-dione, 10-(2-methoxyethyl)-3-phenyl- | [Molecular Formula]
C19H16N4O3 | [MOL File]
61369-43-5.mol | [Molecular Weight]
348.36 |
| Chemical Properties | Back Directory | [Melting point ]
224 °C(Solv: methanol (67-56-1)) | [Boiling point ]
508.8±52.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [pka]
-1.36±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
NSC 288387 is a pan-flavivirus MTase inhibitor. NSC 288387 binds to the SAM-binding pocket. NSC 288387 inhibits ZIKV with an IC50 of 0.2 μM. NSC 288387 also inhibits viral replication in cell culture[1]. | [References]
[1] Samrat SK, et al. Broad-Spectrum Small-Molecule Inhibitors Targeting the SAM-Binding Site of Flavivirus NS5 Methyltransferase. ACS Infect Dis. 2023 Jul 14;9(7):1319-1333. DOI:10.1021/acsinfecdis.2c00571 |
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