| Identification | Back Directory | [Name]
2H-Benzimidazol-2-one, 1-[1-[1-(4-fluorophenyl)ethyl]-4-piperidinyl]-1,3-dihydro- | [CAS]
6440-42-2 | [Synonyms]
2H-Benzimidazol-2-one, 1-[1-[1-(4-fluorophenyl)ethyl]-4-piperidinyl]-1,3-dihydro- | [Molecular Formula]
C20H22FN3O | [MOL File]
6440-42-2.mol | [Molecular Weight]
339.41 |
| Chemical Properties | Back Directory | [density ]
1.243±0.06 g/cm3(Predicted) | [solubility ]
DMF: insol; DMSO: 1 mg/ml; Ethanol: slightly sol; PBS (pH 7.2): insol | [form ]
A crystalline solid | [pka]
12.04±0.30(Predicted) |
| Hazard Information | Back Directory | [Description]
Fluorphine is an analytical reference standard categorized as an opioid.1 This product is intended for research and forensic applications. | [Uses]
Fluorphine is an analogue of Brorphine and can bind to μ-opioid receptor (MOR) (Ki: 12.5 nM). Fluorphine has GTPγS binding (EC50: 75 nM) and βarrestin 2 recruitment (EC50: 377 nM) activity. Fluorphine induces respiratory depressant effects[1][2]. | [References]
1. Kennedy, N.M., Schmid, C.L., Ross, N.C., et al. Optimization of a series of mu opioid receptor (MOR) agonists with high G protein signaling bias J. Med. Chem. 61(19),8895-8907(2018). |
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