| Identification | Back Directory | [Name]
C18 Globotriaosylceramide (d18:1/18:0) | [CAS]
69283-33-6 | [Synonyms]
Octadecanoyl-ceramide trihexoside
C18 Globotriaosylceramide (d18:1/18:0) | [Molecular Formula]
C54H101NO18 | [MOL File]
69283-33-6.mol | [Molecular Weight]
1052.38 |
| Chemical Properties | Back Directory | [Boiling point ]
1132.1±65.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Chloroform:Methanol (2:1): Soluble; DMSO: Soluble; Methanol: Warmed | [form ]
A solid | [pka]
12.76±0.70(Predicted) | [InChIKey]
KWGVNZWSEWAOMI-DHCJWVHISA-N |
| Hazard Information | Back Directory | [Description]
C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. C18 globotriaosylceramide also accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. [Matreya, LLC. Catalog No. 1529] | [Uses]
Gb3(18:1/18:0) (C18 Globotriaosylceramide (d18:1/18:0)) is an ester product. | [Definition]
ChEBI: Alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1/18:0) is a glycotriaosylceramide having alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl as the glycotriaosyl component attached to the Cer(d18:1/18:0). It has a role as a mouse metabolite. It is functionally related to an octadecanoic acid. | [References]
[1] CLIFFORD A LINGWOOD Donald R B. The role of glycosphingolipids in HIV/AIDS.[J]. Discovery medicine, 2011, 11 59: 303-313.
[2] PETRA HOFFMANN. On the structural diversity of Shiga toxin glycosphingolipid receptors in lymphoid and myeloid cells determined by nanoelectrospray ionization tandem mass spectrometry[J]. Rapid Communications in Mass Spectrometry, 2010, 24 15: 2295-2304. DOI: 10.1002/rcm.4636
[3] MUSTAFA A KAMANI. Glycosphingolipid storage in Fabry mice extends beyond globotriaosylceramide and is affected by ABCB1 depletion[J]. Future Science OA, 2016, 2 1. DOI: 10.4155/fsoa-2016-0027 |
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