| Identification | Back Directory | [Name]
Benzenecarboximidamide, N-(3-methyl-4-phenyl-1,2,4-thiadiazol-5(4H)-ylidene)-N'-phenyl- | [CAS]
69909-92-8 | [Synonyms]
RNF5 agonist 1
N-(3-Methyl-4-phenyl-1,2,4-thiadiazol-5(4H)-ylidene)-N'-phenylbenzimidamide
Benzenecarboximidamide, N-(3-methyl-4-phenyl-1,2,4-thiadiazol-5(4H)-ylidene)-N'-phenyl- | [Molecular Formula]
C22H18N4S | [MOL File]
69909-92-8.mol | [Molecular Weight]
370.47 |
| Hazard Information | Back Directory | [Uses]
RNF5 agonist 1 (analog-1), a structural analog of RNF5 inhibitor inh-02 (HY-123967), is a potent RNF5 agonist. RNF5 agonist 1 increases the ubiquitylation status of ATG4B in F508del-CFTR-expressing CFBE41o- cells[1][2]. | [References]
[1] Sondo E, et al. Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia. Cell Chem Biol. 2018 Jul 19;25(7):891-905.e8. DOI:10.1016/j.chembiol.2018.04.010
[2] Li Z, et al. The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation. Signal Transduct Target Ther. 2023 Feb 3;8(1):53. DOI:10.1038/s41392-023-01335-5 |
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