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[Synonyms]

Echitovenidine
Aspidospermidine-3-carboxylic acid, 2,3-didehydro-20-[(3-methyl-1-oxo-2-butenyl)oxy]-, methyl ester, (5α,12R,19α,20R)-
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[Description]

Echitovenidine is an alkaloid isolated from the fruits of Alstonia venenata. In vitro and in vivo studies revealed that echitovenidine has an inhibitory effect on monoamine oxidase.
[Uses]

Echitovenidine is an alkaloid that can be isolated from Alstonia yunnanensis. Echitovenidine is an inhibitor of monoamine oxidase (MAO)[1].
[in vivo]

Echitovenidine (50 mg/kg, IP) significantly potentiates the analgesic effect of a subanalgesic dose of morphine[1].
The LD50 of Echitovenidine in mice was 126 ± 23 mg/kg (IP)[1].
Echitovenidine produces a transient depressor response in anaesthetised dog, with no significant effect on respiration, in dose of 10 mg/kg[1].

[References]

[1] Bhattacharya SK,et al. Psychopharmacological studies on echitovenidine. Pharmacol Res Commun. 1976 Apr;8(2):159-66. DOI:10.1016/0031-6989(76)90005-9
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