| Identification | Back Directory | [Name]
N-[N-[N-(3-Hydroxy-4-methyl-1-oxooctyl)-L-tryptophyl]-L-phenylalanyl]-D-alloisoleucine λ-lactone | [CAS]
76265-41-3 | [Synonyms]
Beauverolide Ja
N-[N-[N-(3-Hydroxy-4-methyl-1-oxooctyl)-L-tryptophyl]-L-phenylalanyl]-D-alloisoleucine λ-lactone | [Molecular Formula]
C35H46N4O5 | [MOL File]
76265-41-3.mol | [Molecular Weight]
602.764 |
| Hazard Information | Back Directory | [Uses]
Beauverolide Ja, a cyclotetradepsipeptide, is a potent calmodulin (CaM) inhibitor with a Kd of 0.078 μM and a Ki of 0.39 μM for Ca2+-CaM. Beauverolide Ja is a secondary metabolite of Isaria fumosorosea[1]. | [IC 50]
Fungal Metabolite | [References]
[1] Abraham Madariaga-Mazón, et al. Potent anti-calmodulin activity of cyclotetradepsipeptides isolated from Isaria fumosorosea using a newly designed biosensor. Nat Prod Commun. 2015 Jan;10(1):113-6. PMID:25920232
[2] Qunfang Weng, et al. Secondary Metabolites and the Risks of Isaria fumosorosea and Isaria farinose. Molecules. 2019 Feb 13;24(4):664. DOI:10.3390/molecules24040664 |
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