| Identification | Back Directory | [Name]
1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine | [CAS]
763111-49-5 | [Synonyms]
KU0058948
KU-0058948
KU 0058948
Venadaparib Impurity 1
1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine
4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]Methyl]-1(2H)-phthalazinone
1(2H)-Phthalazinone, 4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]- | [Molecular Formula]
C21H21FN4O2 | [MOL File]
763111-49-5.mol | [Molecular Weight]
380.42 |
| Chemical Properties | Back Directory | [Melting point ]
>150°C (dec.) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Pale Yellow to Yellowish Beige |
| Hazard Information | Back Directory | [Uses]
KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro | [Uses]
KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 is a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro | [IC 50]
PARP-1: 3.4 nM (IC50) |
|
| Company Name: |
Tcichem, Inc.
|
| Tel: |
13918644899 |
| Website: |
http://www.hezefdc.com/ShowSupplierProductsList19113/0_EN.htm |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|