| Identification | Back Directory | [Name]
3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 4-hydroxy-N,N,N-tri(methyl-d3)-10-oxo-7-[(1-oxohexadecyl)oxy]-, inner salt, 4-oxide, (7R)- | [CAS]
77165-56-1 | [Synonyms]
3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 4-hydroxy-N,N,N-tri(methyl-d3)-10-oxo-7-[(1-oxohexadecyl)oxy]-, inner salt, 4-oxide, (7R)- | [Molecular Formula]
C40H80NO8P | [MOL File]
77165-56-1.mol | [Molecular Weight]
734.05 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Acetonitrile:
Methanol: (1:1): Slightly Soluble: 0.1-1 mg/ml
Methanol: Sparingly Soluble: 1-10 mg/ml | [form ]
powder | [color ]
White to off-white | [InChIKey]
KILNVBDSWZSGLL-IFKPPQQBSA-N | [SMILES]
[H][C@@](COP([O-])(OCC[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O |
| Hazard Information | Back Directory | [Uses]
DPPC-d9-1 is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Miller AD. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811. DOI:10.1586/17434440.2013.855471
[3] Akiko Uemura, et al. Induction of immune responses against glycosphingolipid antigens: comparison of antibody responses in mice immunized with antigen associated with liposomes prepared from various phospholipids. J Vet Med Sci. 2005 Dec;67(12):1197-201. DOI:10.1292/jvms.67.1197 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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