| Hazard Information | Back Directory | [Uses]
Phosal 50 PG is a cosolvent (standardised phosphatidylcholine concentrate). Phosal 50 PG as a carrier for lipophilic compounds, can improve the absorption, efficacy and therapeutic index of the active ingredient[1]. | [in vivo]
Phosal 50 PG is usually used as a cosolvent.
Navitoclax (HY-10087) (100 mg/kg, once a day for 21 days) is formulated in 10% ethanol, 30% polyethylene glycol 400, and 60% Phosal 50 PG and administered p.o. to mice[2].
A-1331852 (HY-19741) (25?mg/kg, daily for 10 days) is formulated in 2.5% DMSO, 10% ethanol, 27.5% PEG 300, and 60% Phosal 50 PG and administered p.o. to mice[3].
Venetoclax (HY-15531) (100 mg/kg, daily for 10 days) is formulated in 10% ethanol, 30% PEG 400, 60% Phosal 50 PG and administered p.o. to mice[4].
| [References]
[1] Khani S, et al. Improved oral bioavalability of mebudipine upon administration in PhytoSolve and Phosal-based formulation (PBF). AAPS PharmSciTech. 2014 Feb;15(1):96-102. DOI:10.1208/s12249-013-0039-x |
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