| Identification | Back Directory | [Name]
1-Hepten-3-one, 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl-, (1E)- | [CAS]
81840-57-5 | [Synonyms]
1-Hepten-3-one, 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl-, (1E)- | [Molecular Formula]
C20H22O3 | [MOL File]
81840-57-5.mol | [Molecular Weight]
310.39 |
| Hazard Information | Back Directory | [Uses]
Yakuchinone B is an Acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor with hypocholesterolemic activity, which is found in the seeds of Zingiberaceae. Yakuchinone B inhibits rat hepatic ACAT with an IC50 value of 20.6 μM. Yakuchinone B is promising for research of hypercholesterolemia and atherosclerosis[1]. | [References]
[1] Ohishi K, et al. Structure-activity relationships of N-(3,5-dimethoxy-4-n-octyloxycinnamoyl)-N'-(3,4-dimethylphenyl)piperazine and analogues as inhibitors of acyl-CoA: cholesterol O-acyltransferase. Chem Pharm Bull (Tokyo). 2001 Jul;49(7):830-9. DOI:10.1248/cpb.49.830 |
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