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848439-89-4

848439-89-4 Structure

848439-89-4 Structure
IdentificationBack Directory
[Name]

1-Propanone, 1-[4-[[4-[(3-chloro-2-fluorophenyl)amino]-6-hydroxy-7-quinazolinyl]oxy]-1-piperidinyl]-2-hydroxy-, (2S)-
[CAS]

848439-89-4
[Synonyms]

1-Propanone, 1-[4-[[4-[(3-chloro-2-fluorophenyl)amino]-6-hydroxy-7-quinazolinyl]oxy]-1-piperidinyl]-2-hydroxy-, (2S)-
[Molecular Formula]

C22H22ClFN4O4
[MOL File]

848439-89-4.mol
[Molecular Weight]

460.89
Chemical PropertiesBack Directory
[Boiling point ]

653.5±55.0 °C(Predicted)
[density ]

1.468±0.06 g/cm3(Predicted)
[pka]

8.16±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

AZ5385 is an EGFR-tyrosine kinase inhibitor. AZ5385 is a HRV-2 virus blocker, with EC50 of 0.35 μM. AZ5385 affects the late stage of viral life cycle[1].
[References]

[1] Miah M, et al. Identification of epidermal growth factor receptor-tyrosine kinase inhibitor targeting the VP1 pocket of human rhinovirus. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0106423. DOI:10.1128/aac.01064-23
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