| Identification | Back Directory | [Name]
2-[[4-Chloro-3-(trifluoromethyl)phenyl]methylene]hydrazinecarboximidamide | [CAS]
849459-88-7 | [Synonyms]
AC-099
2-[[4-Chloro-3-(trifluoromethyl)phenyl]methylene]hydrazinecarboximidamide | [Molecular Formula]
C9H8ClF3N4 | [MOL File]
849459-88-7.mol | [Molecular Weight]
264.64 |
| Hazard Information | Back Directory | [Uses]
AC-099 (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 attenuates spinal nerve ligation-induced hypersensitivity in rats[1][2]. | [in vivo]
AC-099 (compound 3; 30 mg/kg; i.p.; single) completely attenuates spinal nerve ligation (SNL)-induced hypersensitivity in rats[2]. | [References]
[1] Findeisen M, et al. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. J Med Chem. 2012 Jul 12;55(13):6124-36. DOI:10.1021/jm300535s
[2] Gaubert G, et al. Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists. J Med Chem. 2009 Nov 12;52(21):6511-4. DOI:10.1021/jm9011998 |
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