| Identification | Back Directory | [Name]
2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- | [CAS]
849909-77-9 | [Synonyms]
MAO-B-IN-5
MAO B IN 5,MAOBIN5
2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- | [Molecular Formula]
C19H21FN2O2 | [MOL File]
849909-77-9.mol | [Molecular Weight]
328.38 |
| Hazard Information | Back Directory | [Uses]
MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 μM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD)[1]. | [in vivo]
MAO-B-IN-5 (1 mg/kg, i.v.; 5 mg/kg, p.o.) shows oral bioavailability in rats (F=13.6%)[1].
Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats[1].
| Compound | Route | Dose (mg/kg) | Cmax (ng/mL) | AUCt (ng·h/mL) | T1/2 (h) | Vss (h) | Cl (mL/min/kg) | F (%) | | D0 | iv | 1 | 809 | 347 | 0.37 | 1.11 | 47.1 | / | | po | 5 | 163 | 284 | 1.27 | / | / | 16.3 |
SD rats; 1 mg/kg, i.v.; 5 mg/kg, p.o. [1].
| Animal Model: | SD rats[1] | | Dosage: | 1, 5 mg/kg | | Administration: | 1 mg/kg, i.v.; 5 mg/kg, p.o. | | Result: | Showed oral bioavailability in rats (F=16.3%). |
| [IC 50]
MAO-B: 34.190 μM (IC50); MAO-A: 0.204 μM (IC50) | [References]
[1] Wang Z,et al. Enhancing monoamine oxidase B inhibitory activity via chiral fluorination: Structure-activity relationship, biological evaluation, and molecular docking study. Eur J Med Chem. 2022; 228:114025. DOI:10.1016/j.ejmech.2021.114025 |
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