| Identification | Back Directory | [Name]
CEP-11981 | [CAS]
856691-93-5 | [Synonyms]
CEP-11981
BOL 303213X
AEULIVPVIDOLIN-UHFFFAOYSA-N
1.11-(2-METHYLPROPYL)-12,13-DIHYDRO-2-METHYL-8-(PYRIMIDIN-2-YLAMINO)-4H-INDAZOLO(5,4-A)PYRROLO(3,4-C)CARBAZOL-4-ONE
4H-Indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one, 2,5,6,11,12,13-hexahydro-2-methyl-11-(2-methylpropyl)-8-(2-pyrimidinylamino)- | [Molecular Formula]
C28H27N7O | [MDL Number]
MFCD25976804 | [MOL File]
856691-93-5.mol | [Molecular Weight]
477.56 |
| Chemical Properties | Back Directory | [density ]
1.479±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
13.940±0.20(predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
CEP-11981(ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, VEGFR1-3 and FGFR1, and has potential anti-tumor and anti-angiogenic effects[1]. | [in vivo]
CEP-11981(2.5 mg/kg, 5 mg/kg or 10 mg/kg, oral gavage, daily, five days a week for two weeks) significantly arrested the growth of UC xenografts compared to controlwith no change in weight in murine xenograft model of RT4 human UC tumor[1].
| [References]
[1] Weiguo Jian, et al. The angiopoietin-TIE2 pathway is a potential therapeutic target in urothelial carcinoma. Anticancer Res. 2014 Jul;34(7):3377-82. PMID:24982343 |
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NCE Biomedical Co.,Ltd.
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SPIRO PHARMA
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www.spiropharma.com.cn |
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Wuhan Topule
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