| Identification | Back Directory | [Name]
Nudol | [CAS]
86630-46-8 | [Synonyms]
Nudol
3,4-Dimethoxy-2,7-phenanthrenediol
2,7-dihydroxy-3,4-dimethoxyphenanthrene
Nudol/2,7-dihydroxy-3,4-dimethoxyphenanthrene | [Molecular Formula]
C16H14O4 | [MDL Number]
MFCD00879816 | [MOL File]
86630-46-8.mol | [Molecular Weight]
270.28 |
| Hazard Information | Back Directory | [Uses]
Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and MMP-9 activity (Ki: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma[1][2]. | [IC 50]
MMP-2: 988.9 nM (Ki); MMP-9: 1.76 μM (Ki) | [References]
[1] Yuying Zhang, et al. Nudol, a phenanthrene derivative from Dendrobium nobile, induces cell cycle arrest and apoptosis and inhibits migration in osteosarcoma cells. Drug Des Devel Ther. 2019 Jul 29;13:2591-2601. DOI:10.2147/DDDT.S180610
[2] Mohammad Al-Amin, et al. Inhibitory Effect of Dioscorea bulbifera Tubers on the Migration of Triple-Negative Breast Cancer Cells. Breast Cancer Cells. Rev. Bras. Farmacogn. 31, 335–341 (2021). |
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