| Identification | Back Directory | [Name]
cinnamtannin A2 | [CAS]
86631-38-1 | [Synonyms]
cinnamtannin A2
Cinnamtannin A2
Procyanidin D1
[4,8':4',8'':4'',8'''-Quater-2H-1-benzopyran]-3,3',3'',3''',5,5',5'',5''',7,7',7'',7'''-dodecol, 2,2',2'',2'''-tetrakis(3,4-dihydroxyphenyl)-3,3',3'',3''',4,4',4'',4'''-octahydro-, (2R,2'R,2''R,2'''R,3R,3'R,3''R,3'''R,4R,4'R,4''S)- | [Molecular Formula]
C60H50O24 | [MOL File]
86631-38-1.mol | [Molecular Weight]
1155.02 |
| Hazard Information | Back Directory | [Uses]
Cinnamtannin A2, a tetrameric procyanidin, can increases GLP-1 and insulin secretion in mice. Cinnamtannin A2 could upregulate the expression of corticotrophin releasing hormone. Cinnamtannin A2 exhibits antioxidant, anti-diabetic and nephroprotective effect[1][2]. | [Definition]
ChEBI: Cinnamtannin A2 is a proanthocyanidin isolated from Cinnamomum cassia. It has a role as a plant metabolite. | [General Description]
This substance is supplied with certified chromatographic purity. The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG | [in vivo]
Cinnamtannin A2 (10 mg/kg; i.p. for 30 days) ameliorates the level of KIM1 and NAGL in 5/6 nephractomized rats by regulating Nrf2- Keap1 pathway[2].
Cinnamtannin A2 (10 μg/kg; p.o.) increases the secretion of insulin and glucagon-like peptide-1 (GLP-1) in plasma of mice[1].
Cinnamtannin A2 (10 μg/kg; p.o.) significantly promotes phosphorylation of both IRB and IRS-1 in mice[1].
| Animal Model: | Male Sprague-Dawley rats (250-300 g) were induced chronic renal failure (CRF) by removing the kidneys[2] | | Dosage: | 10 mg/kg | | Administration: | I.p. for 30 days | | Result: | Ameliorated the altered level of creatinine, blood urea nitrogen, Neutrophil gelatinase-associated lipocalin, Kidney Injury Molecule-1 and cytokines in the serum and microalbuminurea.
Reduced the oxidative stress level.
Attenuated the altered expression of proteins involved in Nrf2-Keap1 pathway in the kidney tissue.
Reduced the tubular injury score in the kidney tissue. |
| [References]
[1] Yamashita Y, et, al. Cinnamtannin A2, a tetrameric procyanidin, increases GLP-1 and insulin secretion in mice. Biosci Biotechnol Biochem. 2013;77(4):888-91. DOI:10.1271/bbb.130095
[2] Li N, et, al. Cinnamtannin A2 protects the renal injury by attenuates the altered expression of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression in 5/6 nephrectomized rat model. AMB Express. 2020 May 8;10(1):87. DOI:10.1186/s13568-020-01022-6
[3] Osakabe N, et, al. Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro. Exp Biol Med (Maywood). 2002 Jan;227(1):51-6. DOI:10.1177/153537020222700109 |
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