ChemicalBook--->CAS DataBase List--->875770-32-4

875770-32-4

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      875770-32-4 Structure

      875770-32-4 Structure
      IdentificationBack Directory
      [Name]

      Propargyl-PEG4-Tos
      [CAS]

      875770-32-4
      [Synonyms]

      Propargyl-PEG4-Tos
      Propargyl-PEG5-Tos
      3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzene-1-sulfonate
      3,6,9,12-Tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate)
      [Molecular Formula]

      C18H26O7S
      [MDL Number]

      MFCD28950765
      [MOL File]

      875770-32-4.mol
      [Molecular Weight]

      386.46
      Chemical PropertiesBack Directory
      [Boiling point ]

      498.1±45.0 °C(Predicted)
      [density ]

      1.177±0.06 g/cm3(Predicted)
      [form ]

      Liquid
      [color ]

      Colorless to light yellow
      Safety DataBack Directory
      [Symbol(GHS) ]

      Exclamation Mark (GHS07)
      GHS07
      [Signal word ]

      Warning
      [Hazard statements ]

      H315-H319
      [Precautionary statements ]

      P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
      Hazard InformationBack Directory
      [Description]

      Propargyl-PEG5-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
      [Biological Activity]

      Propargyl-PEG4-Tos is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).
      [in vitro]

      PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
      ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

      [target]

      PEGs

      Cleavable

      Spectrum DetailBack Directory
      [Spectrum Detail]

      Propargyl-PEG4-Tos(875770-32-4)1HNMR
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