| Identification | Back Directory | [Name]
1-Boc-4-Cbz-Aminoazepane | [CAS]
878630-96-7 | [Synonyms]
1-Boc-4-Cbz-Aminoazepane
tert-butyl pyridazin-3-ylcarbamate
3-(t-butoxycarbonylamino)pyridazine
tert-butyl N-(3-pyridazinyl)carbamate
tert-butyl 4-(benzyloxycarbonylamino)azepane-1-carboxylate
1,1-dimethylethyl 4-({[(phenylmethyl)oxy]carbonyl}amino)hexahydro-1H-azepine-1-carboxylate
1H-Azepine-1-carboxylic acid, hexahydro-4-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester | [Molecular Formula]
C19H28N2O4 | [MDL Number]
MFCD18207774 | [MOL File]
878630-96-7.mol | [Molecular Weight]
348.44 |
| Chemical Properties | Back Directory | [Boiling point ]
484.9±44.0 °C(Predicted) | [density ]
1.14±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
12.26±0.20(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
a) Synthesis of 1,1-dimethylethyl 4-((benzyloxycarbonyl)amino)hexahydro-1H-azepane-1-carboxylate: 1,1-dimethylethyl 4-aminohexahydro-1H-azepane-1-carboxylate (2.85 g, 13.32 mmol) was dissolved in dichloromethane (50 mL) and benzyl chloroformate (2.30 mL, 15.98 mmol) was added. ) and triethylamine (5.3 mL, 40.0 mmol). The reaction mixture was stirred at room temperature for 4 hours. After completion of the reaction, the organic layer was washed with saturated sodium bicarbonate solution and brine, dried with magnesium sulfate, filtered and concentrated to obtain the crude product. Purification by column chromatography (30%-70% ethyl acetate/hexane) afforded tert-butyl 4-(((benzyloxy)carbonyl)amino)azepane-1-carboxylate as a white solid in 82% (3.8 g) yield.LCMS (M + H): 349. | [References]
[1] Patent: WO2006/29154, 2006, A2. Location in patent: Page/Page column 51-52
[2] Patent: US2011/251176, 2011, A1. Location in patent: Page/Page column 123 |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|