| Identification | Back Directory | [Name]
L-Aspartic acid, L-leucyl-L-seryl-L-threonyl-L-alanyl-L-alanyl-L-α-aspartyl-L-methionyl-L-glutaminylglycyl-L-valyl-L-valyl-L-threonyl-L-α-aspartylglycyl-L-methionyl-L-alanyl-L-serylglycyl-L-leucyl-L-α-aspartyl-L-lysyl-L-α-aspartyl-L-tyrosyl-L-leucyl-L-lysyl-L-prolyl-L-α-aspartyl- | [CAS]
897026-25-4 | [Synonyms]
L-Aspartic acid, L-leucyl-L-seryl-L-threonyl-L-alanyl-L-alanyl-L-α-aspartyl-L-methionyl-L-glutaminylglycyl-L-valyl-L-valyl-L-threonyl-L-α-aspartylglycyl-L-methionyl-L-alanyl-L-serylglycyl-L-leucyl-L-α-aspartyl-L-lysyl-L-α-aspartyl-L-tyrosyl-L-leucyl-L-lysyl-L-prolyl-L-α-aspartyl- | [Molecular Formula]
C122H197N31O47S2 | [MOL File]
897026-25-4.mol | [Molecular Weight]
2914.21 |
| Chemical Properties | Back Directory | [Boiling point ]
2726.3±65.0 °C(Predicted) | [density ]
1.358±0.06 g/cm3(Predicted) | [solubility ]
Soluble to 2 mg/ml in 0.01M PBS | [form ]
Solid | [color ]
White to off-white | [Sequence]
Leu-Ser-Thr-Ala-Ala-Asp-Met-Gln-Gly-Val-Val-Thr-Asp-Gly-Met-Ala-Ser-Gly-Leu-Asp-Lys-Asp-Tyr-Leu-Lys-Pro-Asp-Asp |
| Hazard Information | Back Directory | [Uses]
Azurin p28 peptide is a tumor-penetrated antitumor peptide. Azurin p28 peptide redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide induces apoptosis or cell cycle arrest. Azurin p28 peptide inhibits p53-positive tumor growths. Azurin p28 peptide shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt[1][2][3]. | [storage]
Store at -20°C | [References]
[1] Jia L, et al. Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination. Cancer Chemother Pharmacol. 2011 Aug;68(2):513-24. DOI:10.1007/s00280-010-1518-3
[2] Mehta RR, et al. A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt. Angiogenesis. 2011 Sep;14(3):355-69. DOI:10.1007/s10456-011-9220-6
[3] Yamada T, et al. A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells. Mol Cancer Ther. 2009 Oct;8(10):2947-58. DOI:10.1158/1535-7163.MCT-09-0444 |
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Fuan Bio
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fuanbio.com |
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